FCC-grade dimethicone + USP-grade hydrophobic silica + food-additive emulsifier; FDA 21 CFR 173.340 compliant.

MeFoam-FG is the food-grade silicone defoamer compound built from three regulated-compliance components: (1) FCC-grade (Food Chemicals Codex) dimethicone — purified PDMS with low cyclic siloxane content (D4, D5, D6 below FCC limits), low metal residue (Pt, Sn, Pb below ICP-MS limits), and certified manufacturing under cGMP-equivalent quality systems; (2) USP-grade hydrophobic silica nucleator — pharmaceutical-grade fumed silica surface-treated with HMDS and tested to USP-NF specifications for food-additive use; (3) food-additive-class emulsifier blend (typically polyethylene glycol or sorbitan ester at 1–3%) certified to GRAS (Generally Recognised As Safe) status under FDA 21 CFR 184/186.

SEMITECH supplies MeFoam-FG with a full compliance documentation packet: FDA 21 CFR 173.340 letter (defoaming agents in food processing); USP-NF dimethicone monograph compliance certificate; EU Regulation 1333/2008 E900 dimethylpolysiloxane food-additive listing; halal and kosher certification (Halal-MUI Indonesia, Kosher Star-K USA) on request; cGMP manufacturing audit summary. The compound conforms to a 10 ppm maximum carry-over limit in finished food product (FDA 21 CFR 173.340 specification) and a 100 ppm maximum dose in process water (food-processing application limit). Applications above these thresholds require regulatory pre-approval.

Same fundamental mechanism as MeFoam-S, but FCC/USP component certification meets food-process toxicology requirements.

MeFoam-FG operates by the standard silicone-defoamer spreading-rupture mechanism: FCC-grade dimethicone partitions to the air-water interface of foam bubbles via its low surface tension (~20 mN/m), spreads aggressively across the bubble film displacing surfactant and food-derived foam-stabilising proteins, and the USP-grade hydrophobic silica nucleator punctures the thinning bubble wall to complete rupture. Defoaming kinetics are similar to MeFoam-S: 10–30 second foam knockdown in standard surfactant test, 4–12 hour persistence at typical dosing levels.

• Dosing 5–50 ppm — fermentation reactor foam control (penicillin, citric acid, single-cell-protein)
• Dosing 10–100 ppm — food-processing wastewater (dairy, brewery, beverage)
• Dosing 5–50 ppm — pharmaceutical bioreactor and downstream-processing foam suppression
• Dosing 5–30 ppm — direct food-contact processes (sugar refining, fruit juice, edible-oil processing)

The compliance-driven application differentiates MeFoam-FG from the lower-cost MeFoam-S even though the chemistry is mechanically similar. Pharmaceutical fermentation (penicillin biosynthesis, monoclonal-antibody production, vaccine adjuvant manufacture) requires defoamer with full cGMP and USP-NF compliance documentation chain. Food-processing wastewater regulated under FDA 21 CFR 173.340 requires the defoamer to comply with the 10 ppm carry-over limit. Dairy and beverage process foam control requires E900 EU listing for European-market product. Choose MeFoam-FG specifically when these compliance pathways apply.

Fermentation (largest), food processing, dairy, beverage, pharmaceutical bioreactor, edible-oil processing.

Industrial fermentation is the largest single application — penicillin and antibiotic fermentation, citric acid and amino acid bioprocessing, single-cell-protein production, ethanol fermentation. MeFoam-FG at 5–50 ppm continuous dosing into the fermentation reactor controls the foam load generated by protein and surfactant by-products of microbial metabolism. The FCC/USP compliance is mandatory because the finished product (antibiotic, organic acid, protein) is downstream of the fermentation broth and any defoamer carry-over is subject to USP-NF residual-impurity limits.

Food and beverage processing uses MeFoam-FG at 5–50 ppm in dairy CIP/SIP cleaning systems, brewery wort handling, fruit juice and edible-oil processing, sugar refining, and beverage carbonation systems. Pharmaceutical bioreactor and downstream processing uses MeFoam-FG at 5–50 ppm for cell-culture bioreactor foam control (CHO cells for monoclonal antibody, E. coli for recombinant protein, yeast for vaccine adjuvant) — the cGMP and USP-NF compliance documentation chain is mandatory for pharmaceutical regulatory approvals. Direct food-contact processes (sugar crystallisation, fruit juice deaeration, edible oil refining) use MeFoam-FG at 5–30 ppm — the lower dosing levels reflect the strict 10 ppm carry-over limit in finished food product.

CoA + full compliance documentation packet per shipment; 25 kg HDPE pail; 12-month sealed shelf life.

SEMITECH issues a CoA and compliance documentation packet on every batch with: viscosity at 25°C (Brookfield, target 200–500 cP), FCC dimethicone content (USP-NF method, target ≥85%), USP-grade silica content (gravimetric, target 5–8%), cyclic siloxane content (GC-MS, target D4 ≤500 ppm, D5 ≤500 ppm, D6 ≤300 ppm — well within FCC limits), heavy metal residue (ICP-MS, target Pb ≤1 ppm, Sn ≤1 ppm, Hg ≤0.1 ppm), microbial limits (USP-NF method, target TAMC ≤100 cfu/g, TYMC ≤10 cfu/g, absence of pathogens). Compliance packet includes FDA 21 CFR 173.340 letter, USP-NF monograph compliance certificate, EU E900 listing, GRAS notification reference, halal and kosher certificates (on request), cGMP manufacturing audit summary.

Standard packing 25 kg HDPE pails with food-contact-compliant tamper-evident seals; 200 kg HDPE drums for bulk fermentation plants; 1 t IBC totes for pharmaceutical-scale bioreactor customers (with full chain-of-custody documentation). MOQ 25 kg per grade. Lead time 2–3 weeks ex-Zhejiang to Asia ports, 4–6 weeks to Europe and North America after sea freight (compliance-document review at customs clearance can add 1–2 days). Air freight available for laboratory and qualification quantities (1–5 kg) within 5 working days of CoA approval. Storage: stable under ambient conditions; protect from microbial contamination by maintaining sealed packaging and using clean transfer equipment dedicated to food-grade applications. Shelf life 12 months sealed; 6 months for opened pails (microbial-limit re-test recommended for opened material beyond 6 months). REACH and regulatory: all standard food-additive regulatory pathways supported (FDA 21 CFR 173.340, USP-NF, EU 1333/2008 E900, GRAS, halal, kosher); FCC 13th Edition compliant.

MeFoam-FG is the compliance-critical food-grade defoamer — FCC-grade dimethicone + USP-grade silica, fully documented to FDA 21 CFR 173.340 / USP-NF / EU E900 specifications. Mandatory choice for fermentation, pharmaceutical bioreactor, food processing, dairy, beverage, and direct food-contact applications. 10 ppm finished-product carry-over limit; 100 ppm process-water dose limit.

SEMITECH stocked grade; CoA + compliance packet per batch.